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A Large Scale Synthesis of Racemic 3-Quinuclidinol under Solvent Free Conditions

Chavakula R, Chakradhar Saladi JS, Shankar NGB, Subba Reddy D and Raghu Babu K

An industrially viable synthesis of racemic 3-quinuclidinol under solvent free conditions, a key intermediate of 3-R-Quinuclidinol (R-1-azabicyclo[2,2,2]octan-3-ol) is used as a building block in the synthesis of muscarine M1 and M3 agonists as well as for muscarine M3 antagonists has been described.