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A simple and efficient procedure for the synthesis of 3-substituted indoles catalyzed by methane sulphonic acid

Vangavaragu Jhansi Rani, Kerru Nagaraju, Kotla Veena Vani, Palakondu Lavanya, Chunduri Venkata Rao

A three component one-pot synthesis of 3-substituted indole derivatives by a coupling reaction between indole, aldehydes and amines catalyzed by methane sulphonic acid, under ambient conditions to afford 3-substituted indole in excellent yields, with short reaction time, simple procedure, easy work-up and ecofriendly reaction condition.