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A simple method for the spectrophotometric determination of cefixime in pharmaceuticals

B.S.Virupaxappa, K.H.Shivaprasad, M.S.Latha

A simple specrtophotometric method for the determination of cefoxamide with variamine blue is presented. The determination is based on the hydrolysis of -lactum ring of cefixime with sodium hydroxide which subsequently reactswith iodate to liberate iodine in acidic medium. The liberated iodine oxidizes variamine blue to violet colored species ofmaximumabsorption at 572nm. The absorption is measured within the pH range of 4.0-4.2. Beer’s law is obeyed in the range of 0.5-5.9g/mLforCefixime. The analytical parameter was optimized and the method is successfully applied for the determination of cefixime.