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A validated LC-method for the evaluation of advanced intermediate of montelukast

K.K.Satyanaryana, Dindigala Nagender Rao, Reguri Buchi Reddy, Ghanta Mahesh Reddy, K.S.V.Srinivas, Polisetty Srinivasulu, K.Mukkanti

A liquid chromatography(LC) method has been developed for the determination of montelukast advanced intermediate (2) and its precursors. Separation was achieved onXterra C-18, 1504.6mm, 5.0 mcolumn using with linear gradient programcomprising of mobile phaseA(0.25%of triethyl amine in water, pH adjusted to 3.0 with trifluro acetic acid) and mobile phase B (acetonitrile). The analysis is carried out with flow rate of 1.0 ml/min and at 240 nm. The method is found to be accurate, linear, precise, rugged and specific. This method can be used for the analysis of montelukast advanced intermediate (2).