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Adsorptive stripping voltammetry determination of ofloxacin using carbon paste electrode

I.H.I.Habib, A.B.Farag, Y.A.H.Hassan Rabeay, H.N.A.Hassan

The electrochemical behavior of antibiotic drug (ofloxacin), at carbon paste electrode CPE, is thoroughly investigated. Chemical and electrical parameters affecting the adsorptive voltammetric measurements are optimized. Deferential pulse DP is swept over potential range from-1000 to +400mV in the presence of Britton-Robeson buffer pH 7, with accumulation time 30s, scan rate 50mV/s and pulse amplitude 50mV. The responses are linear over the concentration range 1.65-23.1g/mlwith correlation coefficient .0.998while the limit of detection is 0.17g/ml. Themethod has been applied successfully for the determination of active ingredient in the Egyptian pharmaceutical products and in spiked urinewithmean recoveries of 100.025±2.33, and 98±2.38 respectively.