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An Efficient and Stereoselective Synthesis of S-(+)-Pregabalin Using a Chiral Auxiliary Reagent
Vinigari K, Murugan RN, Noorjahan M and Mangatayaru KG
A highly efficient and enantio selective synthesis of (S)-3-amino-5-methylhexanoic acid 1 (Pregabalin) is reported. Evans enolate based asymmetric alkylation reaction was used as the key step to set up the required chirality. This procedure allows the rapid process to provide the (S)-(+)-Pregabalin 1 in excellent overall yields and purity.
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