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Analgesic and anthelmintic activity of a protease extracted from the latex of the plant Calotropis gigantea Linn

Smriti Rekha Chanda, Indranil Chanda, Sadhan Kr.Dutta, Subrat Kar

The analgesic and anthelmintic activities of the new protease fraction Calotropain-G extracted from the latex of the plant Calotropis gigantea Linn. was evaluated using acetic acid induced writhing test and hot plate test in mice and in earthworm respectively. Calotropain-G showed significant analgesic and anthelmintic activity. The analgesic effect may be due to the inhibition of synthesis or action of prostaglandins. The potency of the compound in anthelmintic activity was found to be inversely proportional to the time taken for paralysis or death of the worms.