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Antibacterial and Antifungal Activities of Some Novel n-Lactosyl Isothiobiurets

K. P. Pande and S. P. Deshmukh

Several 1-aryl-5-hepta-O-benzoyl-β-D-lactosyl-2-S-benzyl-2-isothiobiurets have been synthesized by the interaction of hepta-O-benzoyl-β-D-lactosyl isocyanate with several 1-aryl-S-benzyl isothiocarbamides. All the synthesized compounds were characterized on the basis of elemental analysis, IR, 1H NMR and Mass spectral analysis. The polarimetric studies of total compounds were carried out. In the present investigation, activities of these N-lactosides against pathogenic bacteria and fungi such as E. coli, S. aureus, P. vulgaris, S. typhi, K. Pneumoniae, P. auriginosa, B. subtilis, C. albicancs and A. niger are discussed.