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Antihyperlipidaemic and antiatherosclerotic activity of different fractions of Lagenaria siceraria stemand leaves juice in hyperlipidaemic rats

Manoj K.Mishra

We have investigated different extract of Lagenaria siceraria for their potential of antihyperlipidaemic and antiatherosclerotic effect. These activities were tested by using the triton and cholesterol induced hyperlipidaemia. Fractions were tested at two-dose levels 250mg/kg and 500 mg/kg body weight. The results of the study revealed that by triton, total cholesterol and triglycerides level were significantly increased (P<0.0001) in rats as compared to normal control. Ratswith dried petroleum ether and methanolic extracts (250 mg/kg) caused significant reduction (P<0.01) in total cholesterol and triglycerides compared to tritonWR 1339. In cholesterol induced hyperlipidaemia, at the end of 9th day there were significant increase in above parameters of cholesterol-administered rats exceptingHDL-c (which decreased significantly) compared to normal control (P<0.0001). Besides reducingTC,TG, LDL-c,VLDL-c,TC:HDL, LDL: HDL and atherogenic index, petroleum ether and methanolic extracts increased HDL-c level significantly compared to cholesterol treated rats (P<0.01). Based on this study, we confirmed that fractions of stem and leaves of Lagenaria siceraria is a potentially useful for the treatment of hyperlipidaemia and atherosclerosis.