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Antimicrobial studies of nickel(II) complexes derived from 5-chloro-2-hydroxy acetophenone N4 methyl thiosemicarbazone

J.R.Gujarathi, N.S.Pawar, R.S.Bendre

A new series of novel metal complexes of Ni (II) 5-chloro 2-hydroxy acetophenone N(4) methyl thisemicarbazone with heterocyclic base adducts were synthesized and evaluated for antimicrobial activity against Pseudomonas Putida, Escherichia Coli, Aspergillus Niger and Candida Albicans. Antimicrobial activity was carried out at 10-3 and 10-4 M concentrations usingAmphicilin and Bicip as standard drugs. Overall results indicated that the metal complexes are better antimicrobial agents as compared to their thiosemicarbazone i.e. ligand. Compound Ni.L.Phen showed better antimicrobial activity.