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Application of certain �?�?�?¯�?�?�?�?�?�?°-acceptors for the spectrophotometric `determination of ondansetron in pharmaceutical formulations

Asad Raza, Abdul Subhan Ijaz, Atta-ur-Rehman, Khalida Aslam

In this study, two simple, fast, accurate and sensitive spectrophotometric methods have been developed for the determination of ondansetron in pharmaceutical formulations. These methods(A and B) are based on the charge-transfer reaction of ondansetron base as n-electron donor with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone(DDQ) and 7,7,8,8-tetracyano quinodimethane(TCNQ) as -acceptors to give highly colored complex species which absorb maximally at 465 and 742 nm, respectively. Beer’s lawwas obeyed in the concentration limit of 4-120g/ml and 10-350g/ml respectively for method A and B. The proposed methods were successfully applied for the determination of ondansetron hydrochloride in pharmaceutical formulations. The results demonstrated that the procedures are accurate, precise and reproducible (relative standard deviation <2%), while being simple, cheap and less time consuming and can be suitably applied for the estimation of ondansetron in different dosage forms and dissolution studies with out interferences from common additives encountered.