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Aqueous methanolic extract of Punica granatum protect against alcohol induced gastric ulcer in rats

M.S.Alam, M.A.Ahmad, A.K.Najmi, M.Asif, Sayeed Ahmad

The study was designed to evaluate the anti-ulcer activity of P.granatum in rats. Different extracts viz Aqueous methanol extract (AM), chloroform soluble fraction (CSF), chloroforminsoluble fraction (CIF), water soluble fraction (WSF), and water insoluble fraction (WIF) in a dose of 980mg/kg. Omeprazole 20 mg/kg was used as standard. Ulcer was induced by administering absolute alcohol (96% v/v) in a dose of 5 ml/kg. Aq. mehanolic extract extract exhibit significant antiulcer activity, no other extract showed significant antiulcer activity. Present investigation suggest that Aq. Methanolic ext. of P.granatum possess potent antiulcer activity.