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Assay of Some Oral Hypoglycemic Agents by UV-Visible Spectroscopic Measurements

S. Gunasekaran and V. Renganayaki

Pharmaceutical chemistry is a science that makes use of the general laws of chemistry to study drugs, their preparation, chemical nature, composition, structure, methods of quality control, etc. UVVisible spectrometry is one of the important analytical methods employed in the qualitative and quantitative analysis of pharmaceutical drugs. Qualitative analysis of the compound is done through UVVisible spectroscopy by identifying the λmax. UV-Visible spectrophotometers are more significantly employed for the quantitative estimation of assay of drugs. The actual drug content of a tablet is calculated by comparing the absorbance at λmax of pure substance and the drug. In this work, the quantitative analysis of three hypoglycemic agents used for the treatment of type 2 diabetes namely, gliclazide, pioglitazone hydrochloride and metformin hydrochloride has been carried out (to estimate assay) using UV-Vis spectrophotometry. Tablets of different strengths from same manufacturer were used for the analysis. The estimation was found to be satisfactory.