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Avalidated spectrophotometricmethod for the determination of ranitidine hydrochloride in pharmaceutical pure and dosage forms

Asad Raza, Abdul Subhan Ijaz, Zeshan Masoosd

A rapid, simple and sensitive spectrophotometric method has been developed for the determination of ranitidine hydrochloride in pharmaceutical pure and dosage forms. The method depends on the charge-transfer complex formation between ranitidine bases as n-electron donor with chloranil as -acceptor to give a colored complex that absorbs maximally at 550 nm. Beer’s law is obeyed in the concentration ranges 2-40g/mL with molar absorptivity of 2.5104 L mole-1 cm-1. The proposed method is precise, accurate and specific for the quantitative determination of drug in bulk and dosage forms. The results of analysis of commercial formulations and the recovery study (standard addition method) of ranitidine suggested that there is no interference fromany excipients, which are present in pharmaceutical formulations of ranitidine. Statistical comparison of the results was performed with regard to accuracy and precision using student’s ttest and F-ratio at 95%confidence level. There is no significant difference between the reported and proposed methods with regard to accuracy and precision.