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Bacteriuria by extended-spectrum -lactamase-producing E.coli and Klebsiella pneumoniae

M.Vakilwala, Ratna Trivedi

Antibiotic resistant mutants producing extendedspectrum beta-lactamase (ESBL) have emerged among Escherichia coli and Klebsiella pneumoniae. This study was done to determine the frequency of ESBL-producing E coli and K pneumoniae species isolated from urine samples of our patients. Astudy was conducted on (180) urine isolates (90) E coli and (22) K.pneumoniae) in the laboratory.Microbial sensitivity tests were done on Mueller-Hinton agar plates with disk diffusion method. Broad-spectrum resistance was defined as resistance to ampicillin or cephalothin; ESBL resistance, as resistance of these bacteria to one of ceftriaxone, ceftazidime, or ceftizoxime; and MDR-ESBL; as resistance to (Ampicillin, Amikacin,Ciprofloxacin) of the following antibiotic groups: trimethoprimsulfamethoxazole, aminoglycosides, fluoroquinolones, and nitrofurantoin. An ESBL resistancewas detected in (13.3)%of isolateswithKpneumoniae and (65.33)%of thosewith E coli. TheMDR-ESBLpatternwas detected in (91.8)%of the isolates. These included (13.3)%of the K pneumoniae and (65.33)%of the E coli isolates. Broad-spectrumresistancewas detected in all K pneumoniae isolates and (65.33) %of (90) E coli isolates. Our study showed a high rate of ESBL resistant strain of E coli and K pneumoniae and the emergency of multiple drug resistance to these bacteria in our patients.