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Biochemistry 2018: Synergetic effects of Achyranthes bidentata and Verbascum thapsus in alloxan induced diabetic albino mice

Sadia Tabassum

 Statement of Problem & Aim: The available pharmacological agents possess several undesirable side effects on diabetes. Due to fewer side effects and more effectiveness the demand of herbal medicine has been elevated for this chronic disorder. Hence, current study aimed to evaluate the synergetic activity of Achyranthes bidentata and Verbascum thapsus in alloxan induced diabetic albino mice. Methodology: Plant’s extracts were orally administered to male albino mice. Alloxan monohydrate was used to induce diabetes. Overnight fasting mice blood sugar level and body weight were calculated on weekly intervals for up to 5 weeks. Other parameters i.e. lipid, liver and renal profiles were monitored after oral administration of extracts for 35 days. Findings: Daily oral administration of Achyranthes bidentata (300 mg/kg), Verbascum thapsus (300 mg/kg) and combined extracts dose (600 mg/kg) significantly (p>0.05) decreased the fasting blood glucose level besides significantly improved body weight, lipid profile, liver and kidney function and consequently, controlled diabetes after 35 days treatment. Achyranthes bidentata was found more effective than Verbascum thapsus, while results of combined extract dose (600 mg/kg), were highly significant (p>0.001). Conclusion & Significance: Achyranthes bidentata, Verbascum thapsus and their combined extracts possess antidiabetic and antihyperlipidemic property and proved to be effective to improve body weight, liver and kidney function. Whereas, the synergetic treatment of both extracts was proved comparatively more effective. Present investigation will contribute to the therapeutic exploitation of the natural resources against deadly chronic disorder and will open a new avenue for pharmaceutical