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Cathodic Adsorptive Stripping Voltammetry for the Determination of Atorvastatine Drug in Pharmaceutical Formulation and Spike Human Plasma

Thi Kim Thuong Nguyen, Thi Thao Ta, Minh Huong Giang Dang and Thi Thanh Hai Nguyen

Adsorptive stripping voltammetry is used for the determination of atorvastatine. The dependence of the peak current and potentials on pH, concentration, accumulation potential, accumulation time, scan rate were investigated on the hanging mercury dropping electrode. The reduction of atorvastatine was irreversible on the hanging mercury dropping electrode (HMDE). The response is linear from 10-8 mol.L-1 to 10-7 mol.L-1 and 10-7 mol.L-1 to 10-6 mol.L-1. The detection limits (LOQ) of a standard solution are estimated to be 9.6 x 10-10 mol.L-1 and quantitation limits (LOQ) are 3.2.10-9 mol.L-1 (ater accumulation for 90 s). The methods were fully validated and successfully applied to the high through put determination of the drug in pharmaceutical formulation, human plasma with good recoveries.