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Chemical Stability Studies On Some Locally Manufactured Tablets Using Instrumental Methods

K Anand Kishore and S Srinu Naik

The objective of the present study is to evaluate the quality of tablets formulated by two different Pharmaceutical companies and compare it. Niacinamide, Ferrous fumerate, Paracetamol in combination with Ibuprofen, Nimesulide and Ciprofloxacin of 'X' and 'Y' companies were selected for analysis and quality evaluation. The tablets were screened for two post-formulation instrumentation tests: Disintegration and dissolution rates, following standard Indian Pharmacopeia (IP) procedures. The observations were used to make various plots to correlate the test parameters. From the results obtained and analysis, it was observed that there was no much variation in the pattern of disintegration and dissolution rates of the tablets. The quality maintained by both the companies was found to meet IP standards and reliable