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Design and synthesis of 1-(3,5-bis trifluoromethyl phenyl)-3-(substituted phenyl)-2-propene-1-one as potent antifungal and antibacterial agents

Ch.M.M.Prasada Rao, S.A.Rahaman, Y.Rajendra Prasad

Seven new chalcones were synthesised by Claisen Schmidt condensation using 3,5-bis-trifluoromethyl acetophenone with aromatic aldehydes in dilute ethanolic potassium hydroxide solution at room temperature. All these compounds were characterised by means of their IR, 1H NMR Spectroscopic data and Elemental analysis. The antibacterial activity of these compounds were evaluated by cup plate method using Streptomycin as standard drug. The obtained zone of inhibition values showed that synthesized compounds are moderately significant. It is evident that the compound TFEA showed maximumantifungal activity when comparable with standard Ketoconazole.