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DeterminationOf LomefloxacinBy Flow Injection Chemiluminescence

QU Ling-boa, Zhou Jie, LI Jian-jun

A rapid and sensitive flow injection chemiluminescence (CL) method is described for the determination of lomefloxacin hydrochloride based on the CL generated during its reaction with either cerium(IV) and sodium sulphite in acid medium (system1) or Ce(IV) in acid condition sensitized by rhodamine 6G (system2) or luminol-KIO4-calcein in alkali medium (system3).The effect of analytical and flow injection variabled on these CL systems and determination of lomefloxacin hydrochloride are discussed. The proposed procedures allow the determination of lomefloxacin hydrochloride over the following concentration range 0.01- 15.0 mg L-1 with a detection limit of 0.005 mg L-1, 0.10-15.0 mg L-1 with a detection limit of 0.06 mg L-1, 1.0-20.0 mg L-1 with a detection limit of 0.50 mg L-1 respectively. The method is successfully applied to the determination of lomefloxacin hydrochloride in pharmaceutical preparations.