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Developing a New Spectrophotometric Method using Orthogonal Polynomial Method for Simultaneous Estimation of Pioglitazone and Glimepride in Tablet Formulation

K. Sujana, P. Kumar Babu and G. V. N. Kiranmayi

Pioglitazone belongs to thiazolidinedione derivative, which potentiate the action of insulin to increase glucose uptake and glucose oxidation in both; muscle and adipose tissue. Glimepride acts primary by stimulating release of insulin from the ßcells. Developing a new spectrophotometric method for simultaneous estimation of pioglitazone and glimepride in tablet formulation facilitates to validate the method as per ICH guidelines. The orthogonal polynomial method is simple, accurate, economical, less time consuming and no prior separation is required for analysis.