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Development and Validation of Colorimetric Methods for the Determination of Ritonavir in Tablets

R. Priyadarsini, V. Niraimathi, T. Saraswathy, V. Gopi and R. P. Boopathy

Two simple, precise and sensitive visible spectrophotometric methods (A and B) were developed for the quantitative estimation of ritonavir in bulk drug as well as in pharmaceutical dosage forms (tablets). Method A is based on the complex formation reaction of ritonavir with 1, 10-phenanthroline in presence of ferric chloride to form blood red colored chromogen with absorption maximum at 510 nm and Beer’s law is obeyed in the concentration range of 20-100 μg/mL. Method B is based on the complex formation reaction of ritonavir with potassium ferricyanide in presence of ferric chloride to form bluish green colored chromogen with absorption maximum at 452 nm and Beer’s law is obeyed in the concentration range of 20-100 μg/mL. The proposed methods are statistically validated and found to be useful for the routine determination of in tablets.