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Development and Validation of Simultaneous Spectrophotometric Estimation of Metformin Hydrochloride and Pioglitazone

V. Gupta, S. Sahu, D. C. Goupale, M. Verma and R. K. Nema

Two simple and precise spectrophotometric methods are developed for the simultaneous estimation of metfomin hydrochloride (MFH) and pioglitazone (PZ) by using isobestic point and simulataneous equation method. MFH and PZ show their absorption maxima (max) at 237 nm and 268 nm, respectively and isobestic point at 254.4 nm in methanol. Beer's law is obeyed in the concentration range of 2-10 μg/mL for both the drugs at their absorption maxima (max). These methods are validated statistically using samples of different concentrations of both the drugs. The results of analysis show that the methods are rapid, precise and accurate for the simultaneous estimation of both the drugs in combined dosage form