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Development and Validation of Spectrophotometric Method for the Estimation of Venlafaxine in Bulk and Formulations

C. Sowmya, Y. P. Reddy, M. Kiran Kumar and M. Santhosh Raja

A simple, sensitive and reproducible spectrophotometric method for the analysis of venlafaxine in pure form and in pharmaceutical formulations has been developed. Venlafaxine is a synthetic novel antidepressant drug, which acts by inhibiting the reuptake of serotonin and noradrenaline. Venlafaxine exhibited maximum absorbance at 222 nm with an apparent molar absorptivity of 1.2399 x 105 . Beer’s law was obeyed in the concentration range of 2-26 µg/mL. Results of the analysis were validated statistically and by recovery studies. This method is successfully employed for the determination of venlafaxine in various pharmaceutical preparations.