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Development of UV-Visible Spectrophotometric Method for Estimation of Atazanavir in Tablet Dosage Form

P. H. Sakpal, S. U. Divekar, B. A. Agarwal and R. H. Khiste

The method is simple, accurate and precise for estim ation of Atazanavir in bulk drug by UV-VIS spectrophotometry. Th e Atazanavir is an anti-HIV drug. Atazan avir is soluble in water, methanol, chloroform, ethanol, acetonitrile, 0.1 N NaOH and 0.1 N HCl. New method ha s been developed for estimation of Atazanavir in tablet dosage form using 0.1 N HCl. The λ max was found to be 300 nm in 0.1 N HCl. The Beers-Lamberts law was obeyed in the range of 5-30 μ/mL with a regression coefficient 0.992. Accuracy of proposed method was obtained by recovery studies and the results are obtained on the basis of statistical parameters as per ICH guidelines. The proposed method is found to be accurate, precise, reproducible and economical and it can be employed for routine quality control of Atazanavir in its tablet dosage form.