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Ecofriendly Synthesis of some Bioactive Pyrazoline and Isoxazoline Derivatives from α, β-Unsaturated Cyclohexanone

A. Wasi, Bhupendra Kumar Sharma, Ashish Kumar Gupta and Kumud Intodia

Condensation of cyclohexanone with substituted benzaldehyde in presence of neutral alumina under microwave irradiation affords substituted α, β‐unsaturated cyclohexanone in quantitative yields, which undergoes 1.3-dipolar cycloaddition with hydrazines (Phenylhydrazine, 2, 4-dinitrophenyl hydrazine, semicarbazide and thiosemicarbazide) to afford a series of novel 7-(substituted benzylidene)-3-(substituted phenyl)-2-(substituted)-3, 3a, 4, 5, 6, 7-hexahydro-2H-indazole derivatives. Some new 7-(substituted benzylidene)-3-(substituted phenyl)-3, 3a, 4, 5, 6, 7-hexahydrobenzo[c] isoxazole derivatives were also obtained in quantitative yields by cyclococondensation of substituted α, β‐unsaturated cyclohexanone with hydroxylamine hydrochloride under microwave irradiation. The structures of all the compounds were confirmed by their analytical and spectral data. All the synthesized compounds were screened for antibacterial and antifungal activity. Almost all compounds have shown excellent activity against some Multi Drug Resistant bacteria.