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Effect of Sustanon on some Immunological and Hormonal Parameters in Rats

Ekhlas Abid Hamza Al-Alwany, Haider Kamil Al-Saadi and Alaa Jawad Hassan

Sustnanon is one of androgenic anabolic steroids, which is in use especially among young people and adolescent, and such drug has many long-term negative side effects; therefore, it has become a major health problem. This study was conducted to examine the effect of intramuscular injection of androgenic anabolic steroide (sustanon) on some hormonal and immunological parameters in albino rats. Three doses of sustanon (0.05, 0.1, 0.2) mg/Kg/day, respectively were injected for six weeks. The hormonal changes included the significant decrease (P < 0.05) in the mean levels of adiponectin for both males and females treatment groups compared with control groups, while there was a significant increase (P > 0.05) in the mean levels of FSH hormone of males group, compared with the healthy male control group, In contrast, there was asignificant decrease (P < 0.05) in the mean levels of FSH hormone in females treated groups, compared with the control groups. Furthermore, there were significant decrease (P < 0.05) in the mean levels of LH hormone of both males and females groups, compared with the control groups; a significant decrease (P < 0.05) in the mean levels of testosterone hormone of males group, compared with the control group, while there was a significant increase (P > 0.05) in the mean levels of this hormone of females group, compared with the control group. Immunological changes included a significant decrease (P < 0.05) in the mean levels of IL-1β for males treated group compared with the control group, while there was a significant increase (P > 0.05) in the mean levels of this cytokine for females treated group, compared with the control group. Meantime, there was a significant increase (P > 0.05) in the mean levels of IL-6 and C-reactive protein of the males and females groups, compared with the control groups.