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Effect of Temperature on Thermodynamic Parameter of S-Triazinothiocarbamides in 60% Dioxane-Water Mixture

A. M. Kshirsagar and D. T. Tayade

The drug absorption, transmission, activity and effect of drugs, structure making and breaking properties of ligands, solute-solute and solute-solvent interaction can be explain from thermodynamic parameters of drug. Taking all these things into consideration this research work was carried out. Thermodynamic study of recently synthesized drugs viz. 1-(4- hydroxy-6-methyl)-S-triazino-3-phenylthiocarbamide (L1), 1-(4-hydroxy-6-methyl)-S-triazino–3-ethylcarbamide (L2), 1-(4- hydroxy-6-methyl)-S-triazino-3-methylthiocarbamide (L3), were carried out at 60% dioxane-water mixture at different temperature to investigate effect of structure, group on triazinothiocarbamides.