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Facile synthesis of phenyl esters and amides of cinchophen using EDC.HCl and antibacterial activity

Sheelavanth Shankerrao, Yadav D.Bodke, Anand Upadhyay1,K.L.Nagaraja, J.R.Kiran, N.D.Satyanarayan

Aseries of biologically important 2-phenylquinoline-4-carboxylic esters and amideswere synthesized by the reaction of 2-phenylquinoline-4-carboxylic acid with various substituted phenols and secondary amines using EDC.HCl as a coupling agent. The structures of the compounds were established by 1H NMR and 13C NMR. The compounds were screened for antibacterial activity against Salmonella typhi, Bacillus subtalis and Pseudomonas aeruginosa. The results of antibacterial activity revealed that, compounds (2a), (2g), (2h) and (3a) have showed good activity whereas the other synthesized molecules showed moderate activity against tested bacteria when compared with the standard drug ampicllin.