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Formulation and In Vitro Evaluation of Indomethacin Microcapsules

T. V. Rao and S. Vidhyadhara

The objective of this research was to formulate and evaluate the Indomethecin microcapsules for controlled drug delivery by emulsification solvent evaporation technique, employing ethyl cellulose as coating material. Prepared microcapsules were evaluated for average particle size, Flow properties, Microencapsulation efficiency and in vitro drug release studies. The drug-polymer interaction evaluated by FT-IR spectroscopy. They were found to be discrete, free flowing high percentage of drug entrapment efficiency and also retard the release for 12 hrs. The in vitro dissolution study confirmed that the formulations followed zero order kinetics and peppas release mechanism