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Four UV spectrophotometric methods for estimation of paliperidone in bulk and their pharmaceutical dosage form

BhushanM.Firake,Harsha P.Bhutada,Rahul S.Talekar, DipakA.Korde

A simple, precise and economical methods of UV Spectrophotometry for the estimation of Paliperidone (PPD) in bulk and its formulation are proposed. PPD was estimated at 238.2nm, 236.8nm, 232nm, 232nm in ethanol, ethanol and distilled water, diethyl ether, diethyl ether and distilled water, respectively. The precision expressed as relative standard deviation, which was within 2.0 % for the above four methods. These shows linearity over the concentration range of 0.2-1µg/ml, 5-25µg/ml, 2-10µg/ ml, 10-100µg/ml with regression equation 0.018x + 0.004 (r2 = 0.999), 0.179x + 0.017 (r2 = 0.999), 0.180 + 0.042 (r2 = 0.998), 0.100x - 0.077 (r2 = 0.999). The proposed methods can be successfully applied for the determination of PPD in dosage forms.