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Gas chromatographic determination of venlafaxine hydrochloride from tablet

S.J.Kokate, U.M.Talekar, H.R.Aher, S.R.Kuchekar

A simple, fast, specific and precise method was developed for the quantitative determination of drug venlafaxine hydrochloride from a tablet by gas chromatographic method. For development of method HP-5 capillary column (15meter length, 0.53mmi.d., and 1.5 u filmthicknesses)was used. Nitrogen gas was used as carrier gas with flow rate 10 psi, and oven temperature programming was used with split type injector. Experiments were carried out using flame ionization detector. The retention time of venlafaxine hydrochloride and 2, 3, 4-Trimethoxy benzoic acid is 4.5min and 3.0min respectively.Linearityis in the range of 2mg/ml to 7mg/ml (r2=0.9998). The percentage recovery obtained is 99.84%. The proposed method is useful for estimation of venlafaxine hydrochloride in its tablet form.