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Halogenase Enzymes for Synthesis Development

Olivia Smith

Nature has evolved halogenase enzymes that halogenate a wide range of biosynthetic precursors regioselectively, with the halogens added often having a significant impact on the biological activity of the ensuing natural products. Synthetic aims to develop non-natural bioactive small compounds for medicinal and cosmetic applications. A similar finding has been reached in agrochemical applications. Halogens can significantly improve the characteristics of organic compounds, allowing them to modulate biological targets selectively in vivo. As a result, halogens are found in a large number of medications and agrochemicals on the market today. Halogenated organic molecules are also popular synthesis intermediates, and they're especially useful in cross-coupling reactions involving metal catalysts.