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Human epicardial lipid profile status in CAD patients: Correlation with age, diabetes and hypertension

Anbarasan Chakrapani, Sheela Sasikumar, Saravana Kumar Venkatesan, Shilpa Sivaram, Soma Guhathakurta, Kotturathu Mammen Cherian

The role of obesity is well established in the pathogenesis of Coronary Artery Disease (CAD) and is found to be related to adipocytes. For more than two decades, the role of epicardial fat remains controversial and debatable. Hence, we analyzed the lipid profile status of human epicardial and subcutaneous fat in CAD patients based on risk factors and age. We have found that epicardial fat composition is independent of age and epicardial fat may exert a protective mechanism in atherosclerotic process through elevated levels of HDL and phospholipids than subcutaneous fat.