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Identification of E and Z isomers of some cephalosporins by NMR

R.Rajadurai, B.Sivakumar1, R.Murugan, S.Anantham, P.Y.Naidu

This article deals with the identification of geometrical isomers (E and Z) of some cephalosporin drugs byNMR. 1H and 13C NMR chemical shift values are used to distinguish between the Z isomer of cephalosporins having superior antibacterial activity fromE isomer having less antibacterial activity. Nine cephalosporins of pharmaceutical interest viz, cefotaxime, cefixime, ceftazidime, cefdinir, ceftiofur, ceftriaxone, cefpodoxime proxetil, cefuroxime and cefuroxime axetil samples were taken for the study.