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In-Vitro Sucrase Enzyme Activity of Alcoholic Extracts of Certain Plants belonging to Families Meliaceae, Podocarpaceae and Fabaceae Resulted in Isolation of Novel Polyphenolic Compound

Mohamed I Abdelhady, Amel M Kamal, Mahmoud Youns and Mahmoud Elshahat

80% ethanolic extracts of Azadirachta indica, Podocarpus gracilior, Acacia glauca, Acacia Senegal and Acacia nilotica were biologically tested using Sucrase enzyme inhibitory activity test to evaluate their antidiabetic activity. The alcoholic extracts exhibited significant sucrase inhibitory activity. Thus these plants have great potential as a source for natural health products. The Podocarpus gracilior exhibited the highest sucrase enzyme inhibitor which subjected for chromatographic separation of polyphenolic compounds. The isolated compounds from Podocarpus gracilior resulted in identification of four known compounds, gallic acid, ellagic acid, cinnamic acid and apigenin. In addition of isolation of new polyphenolic compound. This compound was identified as 4“, 4“‘ -dimethoxy-32 ,82 2 -Biapigenin.