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Iron (III) Catalyzed Biginelli-like Three Component Cyclocondensation Reaction: Efficient Synthesis of Novel 5-Substituted 3, 4-Dihydropyrimidin-2(1H)-Ones

Nainesh N. Kansagara, Jagdish N. Godhasra, Mahesh C. Patel and Viral R. Shah

The Biginelli reaction, a one-pot condensation of aryl aldehyde, urea and -dicarbonyl compounds are efficiently catalyzed by iron (III) in acetonitrile to afford the corresponding novel 5- substituted 3, 4-dihydropyrimidin-2-(1H)-ones (2a–i) in high yields. The first Biginelli-like reactions of urea, aryl aldehydes and ketones were furnished important to synthesize new 3, 4-dihydropyrimidin-2- (1H)-ones derivatives suitable for further study. The newly synthesized compounds have been characterized by elemental analysis, IR, 1H NMR and MS spectral data. Some of these compounds showed potential antimicrobial activity.