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Isocyanide-based three-component reactions: synthesis of some novel 1,3,4-oxadiazole derivatives fromN-isocyaniminotriphenyl phosphorane, aromatic aldehydes and aromatic carboxylic acids

Ali Ramazani,Ali Souldozi, Roghaie Ghadimi, YavarAhmadi, VahidAzizkhani, PegahAzimzadeh Asiabi

A wide variety of disubstituted oxadiazole derivatives have been synthesized via a one-pot three-component reaction of Nisocyaniminotriphenylphosphorane, an aromatic aldehyde, and aromatic carboxylic acid in CH3CN at ambient temperature in high yields without using any catalyst or activation. The procedure provides an alternative method for the synthesis of fully substituted oxadiazole derivatives.