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Isolation, characterization and biological activity of compounds isolated from the seeds of Nigella sativa L

B.K.Mehta, Meenal Gupta

New aliphatic compounds and glycosides were isolated from the alcohol extract of seeds of Nigella sativa L., is a medicinal important plant. They were identified as tri-[(O-α-D-glucopyranosyl-(1ï‚®2)-O-β-Dfructofuranosyl-( 3→4)]-α-D- glucopyranoside 1, tetra-[([O-α-D-glucopyranosyl -(1→2) -O-β-D-fructofuranosyl-(4→4) ] -α-D-glucopyranosyl-( 1→2)-β-D-fructofuranoside 2, 4-tricosanol 3, 22-methyl- 12- hexacosanone 4 and 6-methyl pentadecanoic acid 5 along with known compounds 5-nonadecanone 6 and sucrose octa acetate 7. They were characterized on the basis of spectral analysis and comparison by literature data. The antimicrobial activity of alcohol extract was also studied and found to be active against gram positive bacteria.