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Lipid ratios in premenopausal females with breast carcinoma in North Indian population

Megha Kataria Arora, Aniljeet Singh Trehan, Shashi Seth, Ashok Chauhan

Background: Breast cancer is present formany years before it can be diagnosed. This implies that breast cancer cells, during their subclinical period, are likely to have been exposed for a considerable time to lipids. So, we planned this study to evaluate the role of various lipids individually and their integrated ratios in premenopausal females.Methods: Acase control studywas performed in 75 premenopausal femaleswith breast cancer at the time of diagnosis (GroupA). Lipid profile was assessed and lipid ratioswere calculated. Their results were compared with a group of 75 age- & sexmatched healthy controls (Group B). Results: All the lipid ratios in patients were significantly high using ‘t’ test and ANOVA. Area under receiver operating characteristic curve was > 0.7 for all the lipid ratios. Regression analysis showed that all the values had high significance (0.000) except for TG/ HDL ratio which suggests that change in lipid ratio has significant impact on occurrence of breast cancer. Conclusions: Screening of females at young age for dyslipidemia and interventions to normalize the lipid profile may prove helpful in interrupting the pathophysiological cascade of events induced by lipoproteins and lipids and this could enable major life and cost savings.