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Microwave Assisted Synthesis, Biological Evaluation and Docking Studies of Novel Pyrazoline Derivatives as Potent Antiinflammatory and Antibacterial Agents

Parameshwar Ravula, V. Harinadha Babu, P. Manichandrika, N. Ramana Chary and Jn. Narendra Sharath Chandra

A novel series of 1-(4-chlorophenyl)-3-(4-substituted phenyl)-5-(5-(4-nitrophenyl) furan-2-yl)- 4,5-dihydro-1H-pyrazole derivatives (3a-e) and (3-(4-substituted phenyl)-5-(5-(4-nitrophenyl) furan-2-yl)- 4, 5-dihydropyrazol-1-yl) (pyridin-4-yl) methanone derivatives (4a-e) have been synthesized by conventional and microwave irradiation methods. The microwave irradiation method was found to be remarkably successful higher yields, environmental friendly and less reaction times when compared to conventional heating method. The synthesized compounds were characterized by FTIR, 1H NMR and mass spectral data and screened for their in vivo antiinflammatory and in vitro antibacterial activity. Among the tested compounds, compounds 4b and 4e exhibited highest in vivo antiinflammatory activity. Some of compounds showed potent antibacterial activity. In silico prediction of toxicities and drug score profiles of synthesized compounds are found to be promising. Molecular docking results along with the biological data suggested that the compounds (4a-e) may be beneficial as molecular templates for antiinflammatory activity.