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Microwave assisted synthesis of 3-substituted-4(3H)-quinazolinone using silica supported potassium carbonate

I.T.Phucho, S.Tumtin, A.Nongpiur, R.Nongrum, C.Kathing, R.L.Nongkhlaw

A new synthetic route to 3-substituted-4(3H)-quinazolinone has been developed using Potassiumcarbonate-silica as a solid support under microwave irradiation which is an environmental friendly procedure. The use of basic catalyst under solvent free condition for the ring closure of this heterocyclic system is notable.