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Natural P-Glycoprotein Inhibitors as Chemopreventives

Pankaj Gupta

P-glycoprotein (P-GP) is a transmembrane permeability glycoprotein belonging to the ATP binding cassette (ABC) super family that functions specifically as a carrier mediated primary active efflux transporter. P-GP was first discovered in 1976 for its role in multi-drug resistance in cancer.