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New Spectrophotometric Methods for Estimation of Naratriptan in Pharmaceutical Formulations

A. Sreelakshmi, G. Devala Rao and G. Sudhakara Sai Babu

Naratriptan is a triptan drug. Three simple, sensitive and accurate spectrophotometric methods have been developed for the determination of naratriptan in pure state and in its pharmaceutical formulations. The developed Method A is based on the formation of colored species on binding of the drug with the ligand, 1, 10-phenanthroline followed by ferric chloride and ortho phosphoric acid. The developed chromogen in Method A shows maximum absorption at λ max 510 nm and linearity in the range of 1-6 μg/mL. Method B is based on the reaction between drug and 2, 2’-Bipyridyl with ferric chloride and ortho phosphoric acid to form a colored chromogen and it shows maximum absorption at λ max 520 nm and linearity in the range of 20-80 μg/mL. Method C is based on oxidation of the drug in the presence of ferric chloride followed by complex formation with bathophenanthroline. The developed chromogen in Method C shows maximum absorption at λ max 620 nm and linearity in the range of 1-5 μg/mL. The results obtained were statistically evaluated and were found to be accurate and reproducible.