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New Spectrophotometric Methods for the Quantitative Analysis of Prulifloxacin in Pharmaceutical Dosage Forms

P. Ravi Sankar, Ch. Devadasu, P. Srinivasa Babu, G. Devala Rao, S. Gananathamu and S. Sowjanya

Three simple, accurate, sensitive, precise and economical spectrophotometric methods have been developed for the determination of prulifloxacin in tablet formulation. The developed methods were based on the formation of a blue coloured chromogen due to the reaction of prulifloxacin with Folin-ciocalteu reagent in presence of sodium carbonate (Method-I), formation of a blood-red coloured complex resulting from the reaction of prulifloxacin in acetonitrile with ortho-phenanthroline (Method-II) and formation of blood-red coloured complex resulting from the reaction of prulifloxacin in acetonitrile with 2, 2’- bipyridyl (Method-III). The proposed methods showed the absorption maxima at 650 nm, 510 nm and 520nm and have good linearity in the concentration range of 50-250 µg/mL, 5-25 µg/mL and 4-20 µg/mL for method-I, method-II and method-III, respectively. The results of analysis for the proposed methods were validated statistically by recovery studies.