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Novel Metal Complexes Derived From 6-(2, 3-Dichlorophenyl)-1, 2, 4-Triazine-3, 5-Diamine (Lamotrigine, L) and their Applications in Biology

Jihan K Suddik, Mohsen M Mostafa

The reaction of lamotrigine (L) with Cu2+, Co2+, Cr3+ and Fe3+ chlorides and Ni2+ and Hg2+ acetates affords new metal complexes. The isolated solid complexes were synthesized and characterized by chemical, spectral, thermal and magnetic methods. IR spectral data of the isolated complexes suggest that L acts in a monodentate manner towards the metal ions. The general formulae of the chloride and acetate complexes are [Cu2(L)2Cl4].½H2O, [Co(L)2Cl2].½EtOH, [Fe(L)2Cl3].H2O, [Cr(L)3Cl3], [Ni2(L)(Ac)4].6H2O and [Hg(L-H)Ac].5H2O, respectively. The results of electronic spectra and magnetic measurements for Cu2+ complex suggest a distorted-octahedral, tetrahedral for Ni2+ and Co2+ and octahedral structures around the Cr3+ and the Fe3+ ions. TGA data suggest the mechanism of decomposition for the metal complexes. Biological activity of the isolated metal complexes derived from lamotrigine against human tumor cell lines of the types MCF-7 and Hela normal cell line was investigated.