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Novel potentiometric determination of torasemide for antidoping purpose, using â-cyclodextrin and calixarene

Amira M.El-Kosasy, Omar Abd El-Aziz, Naglaa Ebrahim, Laila Abdel Fattah

Two novel Torasemide (TOR) sensors were investigated, using â- cyclodextrin and calix[4]arene as ionophores, where linear responseswithin concentration ranges of (10-7-10-2 and 10-8-10-2M) and Nernstian slopes of (58.77 and 59.214 mV/decade) over the pH range of 7-12 were obtained, respectively. The selectivity coefficients of the developed sensors indicate excellent selectivity for TOR, where the second sensor shows a higher sensitivity if compared to the first one. The proposed fabricated sensors display useful analytical characteristics for the determination of TOR (for anti-doping purpose) in bulk powder, biological fluids and in pharmaceutical formulation.