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One-pot Mannich type reaction of thiobarbituric acid, aryl aldehyde and aromatic amine in catalyzed by surfactants

Dini Ahanthem, Warjeet S.Laitonjam

The Thioxopyrimidine-dione derivatives were prepared by one pot multicomponent Mannich type reaction involving thiobarbituric acids, substituited aldehydes and aromatic amines in acetonitrile-water as solvent using surfactant, Sodium dodecyl sulphate (SDS) at water bath temperature in good yields. The structures of the compounds were confirmed by elemental analyses and spectral data.