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One-Pot Synthesis and Spectral Characterization of New Aminophosphonates

P. Sowjanya Lakshmi, C. Naga Raju, K. Reddi Mohan Naidu and C. Suresh Reddy

A simple, efficient and catalyst-free method for the synthesis of
-amino phosphonates is developed via three-component Kabachnik-Fields reaction by reacting nor-valine ethyl ester (1) / Phenyl glycine ethyl ester (4), various substituted aromatic aldehydes (2a-i) and dialkyl/aryl phosphite in dry ethanol/toluene under reflux conditions. The structures of all the newly synthesized compounds were confirmed by elemental analysis, IR, 1H, 13C, 31P-NMR and Mass spectral data.