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Poly D, L-lactide-co-glycolic acid (PLGA) entrapped chitin on innate and adaptive immune responses in Epinephelus bruneus against Vibrio alginolyticus

Ramasamy Harikrishnan, Chellam Balasundaram, Moon-Soo Heo

The efficacy of polyD, L-lactide-co-glycolic acid (PLGA)-entrapped chitin (CI) on innate and adaptive immune response in kelp grouper (Epinephelus bruneus) against Vibrio alginolyticus was investigated at weeks 1, 2, and 4. The myeloperoxidase (MPO) activity significantly increased in chitin (CI) and PLGA-entrapped chitin (PLGA+CI) on week 4. The serum haemoagglutinating activity and haemolysin activity were significantly enhanced inCT and PLGA+CI onweeks 2 and 4. The respiratory burst (RB) activity and bacterial agglutination activity were increased significantly in chitin (CI) and PLGA-entrapped chitin (PLGA+CI) fromweeks 1 to 4. The cumulative mortality was found low in PLGA-entrapped chitin with 15% whereas 30% and 25% in PLGA and chitin. The present results suggest that PLGA-entrapped chitin microsphere act as immunostimulant that enhance the innate and adaptive immune system in kelp grouper against V. alginolyticus infection.